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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
27.44
Human Site:
T388
Identified Species:
46.43
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
T388
L
N
Q
P
S
T
P
T
H
A
A
G
V
_
_
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
T388
L
N
Q
P
S
T
P
T
H
A
A
G
V
_
_
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
T388
L
H
Q
P
S
T
P
T
H
A
A
G
V
_
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
T388
L
N
Q
P
S
T
P
T
H
A
A
S
I
_
_
Rat
Rattus norvegicus
Q01986
393
43447
T388
L
N
Q
P
S
T
P
T
H
A
A
S
I
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
T386
L
N
Q
P
S
T
P
T
H
A
A
G
V
_
_
Chicken
Gallus gallus
Q90891
398
44059
Frog
Xenopus laevis
Q05116
395
43724
T390
L
K
Q
P
S
T
P
T
H
A
A
G
V
_
_
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
V355
D
T
D
V
A
S
F
V
K
T
I
L
G
D
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
R391
L
P
P
S
T
P
K
R
N
T
S
P
N
_
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
A373
H
D
D
Q
G
E
F
A
V
F
V
K
G
T
I
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
T404
M
S
P
P
H
N
D
T
V
K
P
L
Q
T
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
L663
L
S
K
N
V
P
A
L
H
M
G
G
L
_
_
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
92.3
N.A.
N.A.
84.6
84.6
N.A.
100
0
92.3
0
N.A.
7.6
N.A.
0
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
92.3
92.3
N.A.
100
0
92.3
14.2
N.A.
30.7
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
23
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
46.1
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
8
0
50
50
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
15
0
0
0
8
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
15
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
8
43
15
0
0
% G
% His:
8
8
0
0
8
0
0
0
58
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
15
0
8
% I
% Lys:
0
8
8
0
0
0
8
0
8
8
0
8
0
0
0
% K
% Leu:
65
0
0
0
0
0
0
8
0
0
0
15
8
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
36
0
8
0
8
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
8
15
58
0
15
50
0
0
0
8
8
0
0
0
% P
% Gln:
0
0
50
8
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
15
0
8
50
8
0
0
0
0
8
15
0
0
0
% S
% Thr:
0
8
0
0
8
50
0
58
0
15
0
0
0
15
0
% T
% Val:
0
0
0
8
8
0
0
8
15
0
8
0
36
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
72
% _